Derivatives of human growth hormone (hGH) of increasing size were produced by reaction with the N-hydroxysuccinimide ester of polyethylene glycol-5000 (PEG5000), a 5-kDa reagent that selectively conjugates to primary amines. By adjusting the reaction conditions and purification procedure, it was possible to isolate hGH derivatives containing up to seven PEG moieties that altered the Stokes ... Soon after they were first described in 1990, aptamers were largely recognized as a new class of biological ligands that can rival antibodies in various analytical, diagnostic, and therapeutic applications. Aptamers are short single-stranded RNA or DNA oligonucleotides capable of folding into complex 3D structures, enabling them to bind to a large variety of targets ranging from small ions to ... The p–π* conjugation betw... Electron‐Deficient Conjugated Materials via p–π* Conjugation with Boron: Extending Monomers to Oligomers, Macrocycles, and Polymers - Yin - - Chemistry – A European Journal - Wiley Online Library Acute promyelocytic leukemia (APL) cases expressing the t(15,17) product, promyelocytic leukemia (PML)/retinoic acid receptor α (RARα), have clinical remissions through leukemic cell differentiation after all-trans-retinoic acid (RA) treatment. This differentiation therapy propelled interest in uncovering molecular mechanisms for RA-dependent APL differentiation. Abstract Over the last two decades, the development of chemical biology and the need for more defined protein conjugates have fostered active research on new bioconjugation techniques. In particula... The copper (I)-catalyzed alkyne azide 1,3-dipolar cycloaddition (CuAAC) or ‘click’ reaction, is a highly versatile reaction that can be performed under a variety of reaction conditions including various solvents, a wide pH and temperature range, and using different copper sources, with or without additional ligands or reducing agents. This reaction is highly selective and can be performed ... Conjugation of single-stranded DNA drives horizontal gene transfer between bacteria and was widely studied in conjugative plasmids. ... April 1999 · The Journal of Organic Chemistry. Combinatorial chemistry. Solid phase synthesis (15) Combinatorial synthesis (1) Physical organic chemistry. Reaction mechanisms (10) Stereochemistry (3) Organic synthesis (3) Analytical chemistry. Imaging. Biological imaging (173) Magnetic resonance imaging (67) Fluorescence imaging (61) Tomography (30) Optical imaging (28) Molecular imaging (23) Journal of Materials Chemistry C Extended ligand conjugation and dinuclearity as a route to efficient platinum-based near-infrared (NIR) triplet emitters and solution-processed NIR-OLEDs † "Click chemistry" based conjugation of lipophilic curcumin to hydrophilic ε-polylysine for enhanced functionality. Rohan V. Tikekar, Mateo Hernandez, Donald P. Land, N. Nitin. Biological and Agricultural Engineering; Research output: Contribution to journal › Article › peer-review. 9 Scopus citations.
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